ChBE Annual Peck Lecture featuring Dr. Kristi S. Anseth

The Chemical and Biological Engineering Department of Armour College of Engineering is honored to have Dr. Kristi S. Anseth give the 2014 Ralph Peck Lecture.

The Ralph Peck Lecture Series began in the late 1970s and is held in honor of Ralph Peck, a dynamic teacher and researcher, who was chairman of the chemical engineering department from 1953 to 1967. Lecturers are selected via nominations by the department faculty and voted on by a department committee. Previous lecturers have come from all over the country and from academia, government organizations and corporations.

The Lecture will take place on Wednesday, April 30 in the Perlstein Hall Auditorium. Dr. Kristi S. Anseth is the Distinguished Professor, Chemical and Biological Engineering, Distinguished Professor, Tisone Professor, Associate Professor of Surgery, and Howard Hughes Medical Institute Investigator at the University of Colorado, Boulder, CO. Dr. Anseth will present here lecture entitled: Dynamic Hydrogel Matrices: Cell Biology in the Fourth Dimension. A reception in the Perlstein Hall Lobby will follow the lecture.

Abstract: Methods for culturing mammalian cells in a biologically relevant context are increasingly needed to study cell and tissue physiology, expand and differentiate progenitor cells, and to grow replacement tissues for regenerative medicine. Two-dimensional culture has been the paradigm for in vitro cell culture; however, evidence and intuition suggest that cells behave differently when they are isolated from the complex architecture of their native tissues and constrained to petri dishes or material surfaces with unnaturally high stiffness, polarity, and surface to volume ratio. As a result, biologists are often faced with the need for a more physiologically relevant 3D culture environment, and many researchers are realizing the advantages of hydrogels as a means of creating custom 3D microenvironments with highly controlled chemical, biological and physical cues. Further, the native ECM is far from static, so ECM mimics must also be dynamic to direct complex cellular behavior. In general, there is an un-met need for materials that allow user-defined control over the spatio-temporal presentation of important signals, such as integrin-binding ligands, growth factor release, and biomechanical signals. Developing such hydrogel mimics of the ECM for 3D cell culture is an archetypal engineering problem, requiring control of numerous properties on multiple time and length scales important for cellular functions. New materials systems have the potential to significantly improve our understanding of how cells receive information from their microenvironment and the role that these dynamic processes may play in controlling the stem cell niche to cancer metastasis. This talk will illustrate our recent efforts to advance hydrogel chemistries for 3D cell culture and dynamically control biochemical and biophysical properties through orthogonal, photochemical click reaction mechanisms.