Exploring Energy and Fitness Landscapes of Proteins for Binding and Allostery
Host
PhysicsSpeaker
Ron LevyDirector, Center for Biophysics and Computational Biology;Laura H. Carnell Professor of Biophysics and Computational Biology;Professor of Chemistry, Physics, and Biology;Temple University
https://ronlevygroup.cst.temple.edu/levygroup_people.html
Description
Levy's talk will review work in his lab over the last several years concerning the construction and analysis of energy and fitness landscapes for protein-ligand binding and allosteric transitions. Levy will discuss both structure-based approaches employing molecular dynamics free energy simulations and sequence-based approaches employing Potts models. Examples are chosen from HIV family proteins and Kinase family proteins.